Clinical Research Directory

Inclusion Criteria: * patients with SS or SC SCD * diagnosis of SCD performed by electrophoresis or HPLC in a reference laboratory for hemoglobinopathies * patients older than 18 years at inclusion * clinically in a steady state at inclusion (without complication in the last month and without transfusion in the three last months) * patient followed up for SCD at the sickle cell center of Guadeloupe (University hospital of Guadeloupe, Pointe à Pitre) * patients who will provide written informed consent in accordance with the Declaration of Helsinki * patients affiliated to national social security * the control group (AA subjects) will be patients older than 18 years old who come at the University hospital of Guadeloupe, (Pointe à Pitre) for hip or knee replacement and will do not suffer from chronic disease. Exclusion Criteria: * patients younger than 18 years old * patients with hemoglobinopathy other than SS and SC SCD * patients with a transfusion therapy or on bleeding therapy for less than three months * patients no affiliated to national social security * pregnant or breastfeeding patients