Clinical Research Directory

Inclusion Criteria: \- Case group: Patients with traumatic brain injury Inclusion Criteria: 1. Age\> = 18 years old, male or female; 2. patients with traumatic brain injury; 3. The Mini-Mental State Examination (MMSE) score was lower than normal, and the cut-off value for diagnosis was determined according to different education levels: illiteracy (uneducated) \<=19 points, primary school level \<=22 points, junior high school level and above \< = 26 points; 4. Voluntary participation and ability to complete the study and sign the informed consent form in accordance with the requirements of the study protocol. Control group: family members or accompanying persons of patients in the same period Inclusion Criteria: 1. Age\> = 18 years old, male or female; 2. recent emotional stability; 3. Mini-Mental State Examination (MMSE) score was normal; 4. Voluntary participation and ability to complete the study and sign the informed consent form in accordance with the requirements of the study protocol. Exclusion Criteria: \- Case group: Patients with traumatic brain injury Exclusion Criteria: 1. The study subject is in a lethargic state, coma, or persistent vegetative state; 2. the disease progresses rapidly or is accompanied by serious complications; 3. The subject has severe language dysfunction or/or bilateral upper limb motor function loss; 4. the study subject has severe visual and/or hearing impairment; 5. The subject has a severe mental disorder, physical weakness or other conditions (such as intolerance to the test or uncooperation, etc.); 6. Those who have a history of drug abuse within 6 months before screening or those who have used drugs within 3 months before screening; 7. Those who are considered by the investigator to be unsuitable to participate in this study or cannot complete this study for other reasons. Control group: family members or accompanying persons of patients in the same period Exclusion Criteria: 1. History of congenital or acquired central nervous system disease (including history of traumatic brain injury, cerebrovascular accident, etc.); 2. Those who have a history of drug abuse within 6 months before screening or who have used drugs within 3 months before screening; 3. Those who are considered by the investigator to be unsuitable to participate in this study or cannot complete this study for other reasons.