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SMS - Study of Somatic Mutations Using Genome Sequencing
Sponsor: The Wellcome Sanger Institute
Summary
Disease and tissue aging are thought to be influenced by genetic changes, or mutations, acquired throughout life. These mutations provide clues regarding the genetic damage that occurred through the lifetime of the patient, and include mutations caused by environmental factors such as ultraviolet light from sunlight or tobacco smoke affecting the skin or internal tissues, respectively. Other mutations may occur due to errors in copying the genome as cells divide. Improvements in technologies that read the genetic code have made it possible for all or selected parts of the genetic code of a human being to be "sequenced", allowing mutations (changes in the genetic code) to be detected.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
600
Start Date
2016-10-01
Completion Date
2028-07-14
Last Updated
2025-07-20
Healthy Volunteers
Yes
Conditions
Interventions
sample collection
Samples could include blood, skin biopsy, urine, plucked hair.
Seeking consent
Sample Collection: Surgical
Excess surgical tissue (diseased tissue or tissue being removed for a clinical reason).
Locations (1)
Wellcome Sanger Institute
Cambridge, United Kingdom