Clinical Research Directory

Inclusion Criteria: 1. Highly sensitized (cPRA ≥ 90%) kidney transplant candidates between 18 and 65 years old. 2. To be selected by the algorithm according to probability of kidney transplantation in the upcoming 12months. 3. Adequate venous access and absence of contraindications for leukoapheresis. 4. Women of childbearing age must take contraceptive measures. 5. Must have given written informed consent Exclusion Criteria: 1. Subjects with active TB. 2. Patients on the waiting list multiple organ transplants. 3. A significantly abnormal general serum screening lab result defined as WBC\<3.0x103/ml, Hgb\<8.0 g/dL, platelet count \<100x103/ml, SGOT\>3x upper limit. 4. HIV-positive subjects. 5. Subjects who test positive for HBV infection \[positive HBVsAg or HBVeAg/DNA\] or HCV infection \[RNA+\]. 6. Subjects with active CMV or EBV infection as defined by positive PCR. 7. Subjects with a known history of previous myocardial infarction within one year of screening. 8. Subjects with a history of clinically significant thrombotic episodes, and subjects with active peripheral vascular disease. 9. Patients with a kidney disease with high risk of recurrence and/or complement-associated kidney disease (aHUS, etc). 10. Pregnant and lactating women.