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CD70-targeted immunoPET Imaging of Malignant Cancers
Sponsor: RenJi Hospital
Summary
This study aims to determine the value of cluster of differentiation (CD70)-targeted immuno-positron emission tomography/computed tomography (immunoPET/CT) imaging for diagnosing human malignancies, including renal cell carcinoma (particularly clear cell renal cell carcinoma), lymphoma, and nasopharyngeal carcinoma (NPC), among others.
Official title: CD70-targeted PET/ CT in the Diagnosis of Malignant Cancers
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2024-12-23
Completion Date
2026-12-23
Last Updated
2026-05-12
Healthy Volunteers
No
Conditions
Interventions
[18F]F-RESCA-RCCB6
Enrolled patients will receive 0.01-0.1 mCi/kg of \[18F\]RCCB6. ImmunoPET/CT imaging will be acquired 1-2 hours after \[18F\]RCCB6 injection.
[18F]F-RESCA-R8B4
Enrolled patients will receive 0.01-0.1 mCi/kg of \[18F\]R8B4. ImmunoPET/CT imaging will be acquired 1-2 hours after \[18F\]R8B4 injection.
[68Ga]Ga-NOTA-R8B4
Enrolled patients will receive 0.01-0.1 mCi/kg of \[68Ga\]R8B4. ImmunoPET/CT imaging will be acquired 1-2 hours after \[68Ga\]R8B4 injection.
[18F]F-RESCA-RD06
Enrolled patients will receive 0.01-0.1 mCi/kg of \[18F\]F-RESCA-RD06. ImmunoPET/CT imaging will be acquired 1-2 hours after \[18F\]F-RESCA-RD06 injection.
[68Ga]Ga-NOTA-RD06
Enrolled patients will receive 0.01-0.1 mCi/kg of \[68Ga\]Ga-NOTA-RD06. ImmunoPET/CT imaging will be acquired 1-2 hours after \[68Ga\]Ga-NOTA-RD06 injection.
Locations (1)
Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, China