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Premixed Glucagon/Insulin Solution for Faster Insulin Absorption in Type 1 Diabetes
Sponsor: St. Olavs Hospital
Summary
We will investigate if Lyumjev premixed with nanogram amounts of glucagon speed up the absorption of insulin and the effect on whole body glucose consumption compared to native lyumjev in patients with type 1 diabetes. To do that we will perform euglycemic clamps investigations in patients meetinng fasting in the morning on two separate days.Frequent samples for glucose and insulin measuremenst will be drawn and the day with lyumjev only will be compared to the day with premixed Lyumjev.
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
9
Start Date
2025-04-01
Completion Date
2026-06-01
Last Updated
2026-10-19
Healthy Volunteers
No
Conditions
Interventions
Lyumjev 100 UNT/ML Injectable Solution
0.1 unit insulin Lyumjev /kg body weight is injected subcutaneously
Premixed Lyumjev
A solution of 5 ng glucagon /Unit Lyumjev is injcetd subcutaneously. 0.1 unit insulin / kg body weight is used.
Locations (1)
St. Olavs University Hospital
Trondheim, Norway