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CBM588 Reduces Colorectal Polyp Recurrence
Sponsor: Kaohsiung Medical University
Summary
The goal of this randomized crossover clinical trial is to evaluate the efficacy of Clostridium butyricum MIYAIRI 588 (CBM588) in reducing colorectal adenomatous polyp recurrence in adult patients with a history of colorectal polyps. The main questions it aims to answer are: * Does CBM588 reduce the recurrence of colorectal adenomatous polyps? * Does CBM588 lead to a sustained decrease in polyp burden over time? Researchers will compare a group receiving CBM588 in the first year to a group receiving CBM588 in the second year (after a washout period) to determine whether CBM588 effectively lowers polyp recurrence rates and adenoma prevalence.
Official title: Clostridium Butyricum MIYAIRI 588 Reduces Colorectal Adenomatous Polyp Recurrence: A Randomized Crossover Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
500
Start Date
2017-03-10
Completion Date
2028-12-31
Last Updated
2025-05-16
Healthy Volunteers
No
Conditions
Interventions
Clostridium butyricum MIYAIRI 588
A butyrate-producing probiotic, has demonstrated potential anti-inflammatory and anti-tumorigenic effects.
Locations (1)
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan, Taiwan