Clinical Research Directory

Inclusion Criteria: * Age between 45 and 79 yo. * Clinical diagnosis of primary, early to moderate stage knee osteoarthritis. * BMI range \< 35 kg/m2. * Sedentary lifestyle * Knee joint is the most painful joint in the body. * Ability to speak and understand English. * Willingness to comply with all study procedures and be available for the duration of the study. Exclusion Criteria: * Non-OA disease of the knee. * Advanced knee osteoarthritis * Knee injection in the past 3 months. * Major knee trauma/surgery in the past 5 years or previous knee surgery with hardware limiting cartilage assessment.. * Participate in regular exercise or physical activity . * Participation in an intervention study for knee OA. * Currently using a cane, walker or crutches to walk. * History of cardiovascular disease or hypertension not controlled by medication. * Two or more unexplained falls in the past year. * Inflammatory, autoimmune disorders, neurological, systemic, muscular, or connective tissue conditions that affect walking or ability to exercise. * Contraindication to MRI. * Medical condition or characteristic of the participant that could place the individual at increased risk or preclude s/he from complying with study procedures. * Pregnant female. * Acute or terminal illness.