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RECRUITING

NCT06858579

PHASE3

A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)

Sponsor: Dianthus Therapeutics

View on ClinicalTrials.gov

Summary

The purpose of this Phase 3 study is to demonstrate the efficacy of DNTH103 as compared to placebo in participants with chronic inflammatory demyelinating polyneuropathy (CIDP).

Official title: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of DNTH103 In Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

480

Start Date

2025-02-10

Completion Date

2030-12-31

Last Updated

2026-03-27

Healthy Volunteers

Conditions

Chronic Inflammatory Demyelinating Polyneuropathy

Interventions

DRUG

DNTH103

IV Infusion

DRUG

DNTH103

SC injection

DRUG

Placebo

SC injection

Inclusion Criteria: 1. Must have given written informed consent before any study-related activities are carried out. 2. Weight range between 40 kilograms (kg) and 120 kg. 3. Confirmed diagnosis of CIDP or possible CIDP. Participants must have either typical CIDP or one of the following variants: motor or multifocal CIDP. Diagnosis must be confirmed by the Independent CIDP Review Panel. 4. CIDP Disease Activity Status (CDAS) score ≥ 3 at screening. 5. Must be neurologically stable. 6. Must have an INCAT score between 2 and 9 inclusive. 7. Must fulfill one of the following treatment conditions for CIDP: 1. Currently treated with and responded to immunoglobulin (Ig) (intravenous immunoglobulin \[IVIg\] or subcutaneous immunoglobulin \[SCIg\]) alone or Ig (IVIg or SCIg) plus oral corticosteroids, or previously treated with and responded to, but are no longer being treated with (eg, lost access to), a maintenance regimen of Ig (IVIg or SCIg) alone or Ig (IVIg or SCIg) plus oral corticosteroids. 2. Currently treated with and responded to oral corticosteroids alone or oral corticosteroids in combination with azathioprine or mycophenolate mofetil. 3. Refractory participants who have had treatment failure (worsening) or an inadequate response to Ig and/or oral corticosteroids (defined as no clinically meaningful improvement after a period of a minimum of 12 weeks, which may include both active treatment and observation to assess response), or who at any time were unable to tolerate these treatments, experienced adverse effects, or have documented contraindications. 4. Treatment naïve with no history of prior treatment for CIDP. 8. Documented vaccinations against encapsulated bacteria in accordance with local requirements and vaccine availability. 9. Female participants must be of nonchildbearing potential or if of childbearing potential, must agree not to donate ova, not to attempt to become pregnant and, if engaging in sexual intercourse with a male partner, must agree to use a highly effective method of contraception. 10. Male participants must be surgically sterile for at least 90 days prior to Screening or agree not to donate sperm and, if engaging in sexual intercourse with a female partner who could become pregnant, must agree to use an acceptable method of contraception. Exclusion Criteria: 1. Clinical signs or symptoms suggestive of polyneuropathy of causes other than CIDP. 2. Known evidence of central demyelination or known history of myelopathy. 3. History or presence of significant medical/surgical condition including any acute illness or major surgery considered to be clinically significant or that could have a potential impact on safety/efficacy or study procedures. 4. Any other condition, including mental illness or prior therapy that would make the participant unsuitable for this study. 5. Known complement deficiency or history of positive titer for anti-C1 antibodies. 6. Diagnosis of systemic lupus erythematosus (SLE) or family history of SLE (defined as a parent, sibling, or child). 7. Participants with an autoimmune disease affecting joints, muscle or nervous system. 8. Any coexisting or overlapping condition, which may interfere with outcome assessments, such as severe diabetic neuropathy, fibromyalgia, inflammatory arthritis or osteoarthritis affecting the hands and feet. 9. Prior history of N. meningitidis infection. 10. History of active malignancy within 5 years prior to screening, except basal cell carcinoma of the skin, curatively resected squamous cell carcinoma of the skin, cervical carcinoma in situ curatively treated or low-grade prostate adenocarcinoma for which appropriate management is observation alone. 11. Positive test results for active human immunodeficiency virus (HIV-1 or HIV-2), hepatitis B surface antigen (HBsAg), or hepatitis C virus (HCV) antibodies.

Locations (158)

Clinical Study Site

Birmingham, Alabama, United States

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Phoenix, Arizona, United States

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Scottsdale, Arizona, United States

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Los Angeles, California, United States

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San Francisco, California, United States

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San Francisco, California, United States

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Washington D.C., District of Columbia, United States

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Maitland, Florida, United States

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Tampa, Florida, United States

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Honolulu, Hawaii, United States

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Chicago, Illinois, United States

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Edwardsville, Illinois, United States

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Indianapolis, Indiana, United States

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Kansas City, Kansas, United States

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Burlington, Massachusetts, United States

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East Lansing, Michigan, United States

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Omaha, Nebraska, United States

Cinical Study Site

Lebanon, New Hampshire, United States

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New York, New York, United States

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New York, New York, United States

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Cincinnati, Ohio, United States

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Columbus, Ohio, United States

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Portland, Oregon, United States

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Dallas, Texas, United States

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Denton, Texas, United States

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Houston, Texas, United States

Texas Locations

Houston, Texas, United States

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Round Rock, Texas, United States

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Sugar Land, Texas, United States

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Seattle, Washington, United States

Cinical Study Site

Buenos Aires, Buenos Aires, Argentina

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Rosario, Santa Fe Province, Argentina

Cinical Study Site #3

Buenos Aires, Argentina

Cinical Study Site #4

Buenos Aires, Argentina

Clinical Study Site #2

Buenos Aires, Argentina

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Buenos Aires, Argentina

Cinical Study Site #2

San Miguel de Tucumán, Argentina

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San Miguel de Tucumán, Argentina

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Randwick, New South Wales, Australia

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Saint Leonards, New South Wales, Australia

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Sydney, New South Wales, Australia

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Southport, Queensland, Australia

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Melbourne, Victoria, Australia

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Brussels, Belgium

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Rio de Janeiro, Rio de Janeiro, Brazil

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Campinas, São Paulo, Brazil

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Natal, Brazil

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Porto Alegre, Brazil

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Salvador, Brazil

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São Paulo, Brazil

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São Paulo, Brazil

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Sofia, Bulgaria

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Sofia, Bulgaria

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Hefei, Anhui, China

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Guangzhou, Guangdong, China

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Changsha, Hu'Nan, China

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Changsha, Hu'Nan, China

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Wuhan, Hubei, China

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Chifeng, Inner Mongolia, China

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Suzhou, Jiangsu, China

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Beijing, China

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Beijing, China

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Chengdu, China

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Fujian, China

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Guangdong, China

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Guangzhou, China

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Jilin, China

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Shanghai, China

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Shanghai, China

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Sichuan, China

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Taiyuan, China

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Wuhan, China

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Medellín, Antioquia, Colombia

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Antioquia, Colombia

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Medellín, Colombia

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Osijek, Croatia

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Aarhus, Denmark

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Copenhagen, Denmark

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Bordeaux, France

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Brest, France

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Bron, France

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Clermont-Ferrand, France

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Libourne, France

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Marseille, France

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Nice, France

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Paris, France

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Paris, France

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Strasbourg, France

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Tours, France

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Tours, France

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Tbilisi, Georgia

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Sande, Lower Saxony, Germany

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Aachen, Germany

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Greifswald, Germany

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Rüdersdorf, Germany

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Sande, Germany

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Beersheba, Israel

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Haifa, Israel

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Safed, Israel

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Bergamo, Italy

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Bologna, Italy

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Genova, Italy

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Gussago, Italy

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Milan, Italy

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Milan, Italy

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Modena, Italy

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Pavia, Italy

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Ponderano, Italy

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Roma, Italy

Clinical Study Site #2

Roma, Italy

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Roma, Italy

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Terni, Italy

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Riga, Latvia

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Riga, Latvia

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Kota Kinabalu, Sabah, Malaysia

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Kuching, Sarawak, Malaysia

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George Town, Malaysia

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Johor Bahru, Malaysia

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Kota Kinabalu, Malaysia

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Kuala Lumpur, Malaysia

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Kuala Lumpur, Malaysia

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Kuala Lumpur, Malaysia

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Kuching, Malaysia

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Sungai Buloh, Malaysia

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Utrecht, Netherlands

Clinical Study Site

Skopje, North Macedonia

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Cebu City, Philippines

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Iloilo City, Philippines

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Bydgoszcz, Poland

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Krakow, Poland

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Lublin, Poland

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Lublin, Poland

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Lublin, Poland

Cinical Study Site

Warsaw, Poland

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Wroclaw, Poland

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Bucharest, Romania

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Belgrade, Serbia

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Belgrade, Serbia

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Kragujevac, Serbia

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Niš, Serbia

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Daegu, South Korea

Cinical Study Site

Daejeon, South Korea

Cinical Study Site #2

Seoul, South Korea

Cinical Study Site #3

Seoul, South Korea

Cinical Study Site

Seoul, South Korea

Cinical Study Site

Yangsan, South Korea

Clinical Study Site

Barcelona, Barcelona, Spain

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Alicante, Spain

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Barcelona, Spain

Cinical Study Site

Barcelona, Spain

Clinical Study Site

Bilbao, Spain

Cinical Study Site #2

Bangkok, Thailand

Cinical Study Site

Bangkok, Thailand

Cinical Study Site

Hat Yai, Thailand

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Khlong Luang, Thailand

Cinical Study Site

Khon Kaen, Thailand

Cinical Study Site

Khon Kaen, Thailand

Clinical Study Site

Oxford, United Kingdom

Clinical Research Directory

A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)

Summary

Key Details

Conditions

Interventions

Eligibility Criteria

Locations (158)