Clinical Research Directory

Inclusion Criteria: 1. patients undergoing routine gastroscopy/colonoscopy; 2. age ≥ 18 and ≤ 75 years old, regardless of gender; 3. American Society of Anesthesiologists (ASA) grade I-III; 4. Body mass index (BMI) 18-30 kg/m2 (including the cut-off value) and body weight ≤100 kg; 5. Serum cortisol concentrations were either normal or abnormal but not clinically significant as judged by the investigator 6. Vital signs during screening: respiratory rate ≥10 and ≤24 times/min; Pulse oxygen saturation (SpO2) ≥95% while breathing air; Systolic blood pressure (SBP) ≥90mmHg and ≤160mmHg; Diastolic blood pressure (DBP) ≥60mmHg and ≤100mmHg; Heart rate (ECG) ≥55 and ≤100 beats/min; 7. Able to understand the procedures and methods of this study, willing to sign the informed consent and strictly abide by the trial protocol to complete the study. Exclusion Criteria: 1. patients with possible gastroduodenal outflow obstruction with retention of contents or upper gastrointestinal bleeding; 2. patients who were known or suspected to have allergies or contraindications to the components of the investigational drug or the prescribed regimen, or who were suspected to have epilepsy or severe liver and kidney dysfunction; 3. Predicted difficulty in intubation or ventilation (modified Markov score level III, level IV); 4. having any of the following respiratory management risks before/at the time of screening: 1) history of asthma, wheezing; 2) sleep apnea syndrome; 5. QTcF≥450 ms (male) or ≥470 ms (female) at screening and confirmed by review; Or clinically significant electrocardiographic abnormalities that were deemed by the investigator to be ineligible for the study; 6. use of any of the following drugs or treatments before screening:1) enrolled in a clinical trial of any drug within 1 month before screening; 2) use of medications or treatments that affect cortical function within 3 days before screening; 3) Use of medications that may affect QT interval within 2 weeks before screening; 7. During the screening period, the laboratory examination indicators exceeded the abnormal level and had clinical significance, and were not suitable for enrollment after evaluation by the investigators; 8. pregnant and lactating women; The reluctance of women or men of childbearing potential to use contraception for the entire dosing period; Subjects (including male subjects) who plan to become pregnant within 3 months after the trial; 9. Subjects with any other factors considered by the investigator to be ineligible for participation in the trial.