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A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity
Sponsor: Eli Lilly and Company
Summary
This is a study of retatrutide in participants with obesity. The main purpose is to learn more about how retatrutide maintains body weight loss. The study will have two treatment phases: an 80 week lead-in phase in which all participants will take retatrutide dose 1 and a 36 week randomized, double-blinded phase in which participants will either take retatrutide dose 1, retatrutide dose 2, or switch to placebo. Participation in the study will last around 125 weeks.
Official title: A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Retatrutide Treatment in the Maintenance of Weight Reduction in Individuals With Obesity
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
643
Start Date
2025-03-05
Completion Date
2028-04
Last Updated
2026-03-03
Healthy Volunteers
No
Conditions
Interventions
Retatrutide
Administered SC
Placebo
Administered SC
Locations (53)
Southern California Clinical Research
Santa Ana, California, United States
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
CMR of Greater New Haven, LLC
Hamden, Connecticut, United States
ALL Medical Research, LLC
Cooper City, Florida, United States
Florida International Medical Research
Coral Gables, Florida, United States
Renstar Medical Research
Ocala, Florida, United States
Charter Research - Winter Park
Orlando, Florida, United States
Metabolic Research Institute, Inc.
West Palm Beach, Florida, United States
Kubost Clinical Research - Marietta
Marietta, Georgia, United States
North Georgia Clinical Research
Woodstock, Georgia, United States
Pacific Diabetes & Endocrine Center
Honolulu, Hawaii, United States
Alliance for Multispecialty Research, LLC
Oak Brook, Illinois, United States
Springfield Clinic Main Campus
Springfield, Illinois, United States
Alliance for Multispecialty Research, LLC
Lexington, Kentucky, United States
L-MARC Research Center
Louisville, Kentucky, United States
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States
Care Access - Lake Charles (Bayou Pines)
Lake Charles, Louisiana, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Alliance for Multispecialty Research, LLC
Kansas City, Missouri, United States
Vector Clinical Trials
Las Vegas, Nevada, United States
Dent Neurosciences Research Center, Inc
Amherst, New York, United States
Carteret Medical Group
Morehead City, North Carolina, United States
Care Access - Raleigh
Raleigh, North Carolina, United States
Tekton Research, LLC.
Moore, Oklahoma, United States
Altoona Center For Clinical Research
Duncansville, Pennsylvania, United States
Care Access - Rapid City
Rapid City, South Dakota, United States
Alliance for Multispecialty Research, LLC
Knoxville, Tennessee, United States
Care Access - Houston
Houston, Texas, United States
Southern Endocrinology Associates
Mesquite, Texas, United States
Sleep Therapy Research Center
San Antonio, Texas, United States
National Clinical Research, Inc
Richmond, Virginia, United States
Northwest Clinical Research Center
Bellevue, Washington, United States
Central Washington Health Services Association d/b/a Confluence Health
Wenatchee, Washington, United States
Aggarwal and Associates Limited
Brampton, Canada
Circulate Cardiac & Vascular Centre
Burlington, Canada
Med Trust Research
Courtice, Canada
Winterberry Research Inc.
Hamilton, Canada
Centre de Medecine Metabolique de Lanaudiere (CMML)
Terrebonne, Canada
Care Access - Thunder Bay - Barton Street
Thunder Bay, Canada
Maple Leaf Research
Toronto, Canada
C.I.C. Mauricie inc.
Trois-Rivières, Canada
FutureMeds - Birmingham
Birmingham, United Kingdom
Oakenhurst Medical Practice
Blackburn, United Kingdom
Layton Medical Centre
Blackpool, United Kingdom
Bradford on Avon Health Centre
Bradford-on-Avon, United Kingdom
FutureMeds - Liverpool
Bromborough, United Kingdom
Cheadle Community Hospital
Cheadle, United Kingdom
HMC Health Group - Meadows Centre for Health
Hounslow, United Kingdom
St Bartholomew's Medical Centre
Oxford, United Kingdom
Atlantic Medical
Penzance, United Kingdom
The Adam Practice
Poole, United Kingdom
Woodstock Bower Surgery
Rotherham, United Kingdom
Rame Group Practice
Torpoint, United Kingdom