Clinical Research Directory

Inclusion Criteria: 1. Hospital admission within 24 hours. 2. Radiologically new-onset chest infiltrate that is consistent with pneumonia and symptoms or signs also consistent with pneumonia, such as fever, cough, sputum, dyspnoea and/or chest pain 3. CURB-65 score 3-5 4. C-reactive protein \>50 OR central body temperature \>38.0 °C (1-2 of these fulfilled) 5. Age ≥ 18 years 6. Able to give informed consent. Exclusion Criteria: 1. Septic shock according to the sepsis III criteria:41 sequential organ failure assessment (SOFA) score ≥2) and suspected infection (according to attending physician) and persisting hypotension requiring vasopressors to maintain MAP≥65 mmHg and serum lactate level\>2 mmol/L (18 mg/dL) despite adequate volume resuscitation (30 mL/kg crystalloid within 3 hours). 2. Oxygen requirement ≥5 L/min to maintain acceptable saturation assessed by the treating physician. 3. Respiratory rate \>24/min with relevant oxygen therapy 4. Positive COVID or influenza test (PCR or antigen test) 5. Known allergy to levofloxacin or other fluoroquinolones or a serious adverse reaction when previously treated with a fluoroquinolone, including tendinitis or tendon-rupture related to fluoroquinolone treatment 6. Symptoms of neuropathy (peripheral paraesthesia, hypoesthesia, or hyperalgesia) 7. Known allergy to β-lactam antibiotics or to macrolide antibiotics. 8. Medical history of myasthenia gravis 9. Reduced kidney function (eGFR \< 20) 10. Expected transfer to ICU or death within 48 hours or a do not resuscitate ordination at time of recruitment. 11. Suspected aspiration pneumonia, pulmonary abscess, or pleural empyema / complicated parapneumonic effusion. 12. Clinically significant cardiac conduction disorders/arrhythmias or prolonged QTc interval (QTc (f) \> 480ms). 13. Pregnancy (a negative pregnancy test is required prior to inclusion of all pre-menopausal women)