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Safety of Short-course of NSAIDs in Pediatric Patients With CKD
Sponsor: University of Colorado, Denver
Summary
The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney disease (CKD). The investigators hypothesize that there is no increased risk. This will be a limited pilot study within a Pediatric Urology population, intended to inform future work in a larger patient population.
Official title: Safety of Short-term NSAID Use in the Postoperative Setting in Pediatric Patients With Chronic Kidney Disease
Key Details
Gender
All
Age Range
18 Months - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2025-07-22
Completion Date
2027-06
Last Updated
2025-10-22
Healthy Volunteers
No
Conditions
Interventions
NSAIDs
IV formulation: ketorolac 0.5mg/kg/dose, 15mg maximum, no more than 8 doses total PO formulation: ibuprofen suspension 10mg/kg/dose, 400mg maximum Total duration (IV + PO) will not exceed 5 days.
Placebo
IV or PO medication, compounded to have similar look, consistency and taste to the corresponding medications
Locations (1)
Children's Hospital Colorado
Aurora, Colorado, United States