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ACTIVE NOT RECRUITING
NCT06860841
PHASE4

Effects of D-Chiro-Inositol Combined with Metformin on Insulin Resistance in People with Overweight or Obesity and T2DM

Sponsor: Campus Bio-Medico University

View on ClinicalTrials.gov

Summary

This study evaluates the efficacy of D-Chiro-Inositol (DCI) as an add-on therapy to metformin in improving insulin resistance, measured by the HOMA index, in people with overweight or obesity and type 2 diabetes mellitus (T2DM). Secondary outcomes include glycemic variability, indirect calorimetry, respiratory quotient, and other metabolic parameters.

Official title: Effects of D-Chiro-Inositol Combined with Metformin on Insulin Resistance in People with Overweight or Obesity and Type 2 Diabetes Mellitus: a Placebo-controlled Randomized Double-Blind Crossover Trial

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

16

Start Date

2025-01-10

Completion Date

2025-04-10

Last Updated

2025-03-11

Healthy Volunteers

No

Interventions

DRUG

D-Chiro-Inositol Combined with Metformin

D-chiro-Inositol will be administered for 14 days,1 cp after lunch and 1 cp after dinner in addition to preexisting metformin therapy

DRUG

Placebo in combination with metformin

placebo will be administerd for 14 days, 1 cp after lunch and 1 cp after dinner in addition to pre-existing metformin therapy

Locations (1)

Fondazione Policlinico Universitario Campus Bio-Medico

Rome, RM, Italy