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Exploring the Influence of Trptophan on the Treatment of Pouchitis
Sponsor: Universitätsklinikum Hamburg-Eppendorf
Summary
Patients with a pouch frequently suffer from chronic inflammation of the intestinal tract, called pouchitis. Pouchitis is routienly treated with repeated courses of antibiotics and probiotics, which does not stop the inflammation from recurring and exposes the patients to the risk of developing antibiotic -resistant pouchitis. Experimental data suggest that the effectiveness of the antibiotic and probiotic treatment can be prolonged by high consumption of trypotophan, an aminoacid present in everyday food. The Try Pro Pouch study aims to compare the consumption of high amounts of tryptophan against placebo in patients with pouchitis.
Official title: Untersuchung Des Einflusses Einer Tryptophanreichen Diät Auf Das Therapeutische Potential Von Probiotika Nach Antibiotischer Therapie Bei Chronischer Pouchitis (Try Pro Pouch). Eine Prospektive Randomisierte Kontrollierte Doppelblinde Interventionsstudie
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-04-01
Completion Date
2027-04-30
Last Updated
2025-03-06
Healthy Volunteers
No
Conditions
Interventions
Tryptophan 25mg/kg bodyweight
Tryptophan is supplemented during the treatment of chronic pouchitis with pro- and antibiotics
Placebo
standard treatment of chronic pouchitis using pro- and antibiotics.