Clinical Research Directory

Inclusion Criteria: * Male or female * Subject aged ≥ 18 years * Affiliated with a social security scheme * Having given written informed consent to participate study * Admitted for major surgery expected to last more than 2 hours * Under general anesthesia with tracheal intubation * For a planned hospital stay of at least 48 hours * Participant's ability to understand the nature and objectives of the study to comply with study requirements. Exclusion Criteria: * Contraindication to one of the drugs used for anesthesia * Urgent surgery * Intracranial surgery * Transplant surgery * Cardiac surgery * Surgery with scheduled local anesthesia * Patient requiring postoperative intubation * Neuromuscular disease * Patient chronically using morphinomimetics * Chronic pain patient * Patients with a history of sleep apnea * Conditions likely to interfere with photoplethysmograph signal acquisition or skin conductance (excessive or tremors of the extremities, skin lesions or burns) * Patients wearing false nails and/or nail polish * Contraindication to the use of the PMD 200 ™ medical device (including cardiovascular resuscitation and cardioversion/defibrillation); * Patient with an implanted pacemaker or defibrillator * Treatment with β-blockers * Preoperative cardiac arrhythmia * Pregnant or breast-feeding women. A β-HCG test will be systematically performed prior to inclusion of non-menopausal women menopausal women * Patients under legal protection (safeguard of justice, curatorship guardianship) or deprived of liberty * Participation in other interventional research involving an experimental drug or medical device.