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Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
Sponsor: VZW Cardiovascular Research Center Aalst
Summary
The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA). The main questions it aims to answer are: * Do beta-blockers improve coronary blood flow in patients with ANOCA? * Do beta-blockers reduce coronary microvascular resistance in these patients? Researchers will compare a beta-blocker to a placebo to see if the medication has measurable effects on coronary circulation. Participants will: * Receive a beta-blocker or a placebo * Undergo specialized heart tests (such as coronary flow and resistance measurements) before and after treatment.
Official title: Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA: a Randomised, Placebo-controlled, Mechanistic Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
46
Start Date
2025-07-03
Completion Date
2025-12-31
Last Updated
2025-07-14
Healthy Volunteers
Yes
Interventions
Saline (NaCl)
IV 0.9% NaCl (5 ml)
Metoprolol Tartrate
Metoprolol Tartrate (5 ml of 1 mg/ml solution for injection)
Locations (1)
OLV Cardiovascular Center Aalst
Aalst, Flanders, Belgium