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NOT YET RECRUITING
NCT06865170
PHASE4

Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?

Sponsor: University of California, Davis

View on ClinicalTrials.gov

Summary

This study aims to investigate factors that affect the subjective experience of pain during and after intra-articular knee joint injection of steroids by comparing needle gauge size (22 G vs 25 G needles), as well as the presence or absence of topical ethyl chloride spray. Additionally, this study will investigate the effects of other various factors on patients' pain associated with the injection. Lastly, this study aims to determine the effect of patients' subjective pain from the injection on long-term clinical outcomes. Specific aims are as follows: Aim 1): Determine the effect of needle gauge size on patient reported pain associated with an ultrasound-guided intra-articular knee injection. Aim 2): Determine the effect of ethyl chloride spray on patient reported pain associated with an ultrasound-guided intra-articular knee injection. Aim 3): Determine the effect of sex, age, BMI, thigh size, severity of OA, and fear of needles on patient pain associated with an ultrasound-guided intra-articular knee injection. Aim 4) Determine the effect of patient pain from the procedure on longer term clinical outcomes after an ultrasound-guided intra-articular knee steroid injection. Researchers will obtain data at various time points, including pre-procedural data, immediately after the procedure, 24-48 hours after, and 6 weeks post-procedure. Participants will: Consent to receiving an intra-articular knee joint injection with steroids if indicated. Score their "procedural" pain immediately following the procedure, score their post-procedural "soreness" 24-48 hours after via telephone call, and score their overall knee pain about 6 weeks after the procedure via telephone call.

Key Details

Gender

All

Age Range

40 Years - 89 Years

Study Type

INTERVENTIONAL

Enrollment

88

Start Date

2026-05

Completion Date

2026-05

Last Updated

2026-01-29

Healthy Volunteers

Yes

Interventions

PROCEDURE

25 gauge needle

This intervention will observe patients post-procedural pain using a 25 gauge needle

PROCEDURE

22 gauge needle

This intervention will observe patients post-procedural pain using a 22 gauge needle

PROCEDURE

+/- Ethyl Chloride Topical Aerosol Anesthetic

This intervention will observe patients post-procedural pain when using topical ethyl chloride spray. This will be compared to a placebo spray which will utilize isopropyl alcohol.

Locations (1)

UC Davis Sports Medicine Clinic

Sacramento, California, United States