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Involvement of the Septal Nuclei of the Human Brain in Alcohol Use Disorder
Sponsor: Anders Fink-Jensen, MD, DMSci
Summary
Alcohol activates reward systems in different brain areas, i.e., the nucleus accumbens, dorsal striatum, extended amygdala, and prefrontal cortex. These areas are all part of the reward neurocircuitry, which plays an important role in the development of addiction. A former study performed on rodents has shown that a specific area of the forebrain, the septal nuclei, is associated with the feeling of reward and, hence, addiction when stimulated. However, whether the septal area is involved in reward and addiction in humans is sparsely investigated. The purpose of this brain-imaging study is to assess how the septal nuclei react to alcohol-related pictures shown to participants diagnosed with alcohol use disorder while lying in an MRI scanner, compared to people without a diagnosis of alcohol use disorder. This might give us a better understanding of how the septal nuclei is involved in reward and addiction.
Official title: Involvement of the Septal Nuclei of the Human Brain in Alcohol Use Disorder - a Functional Magnetic Resonance Imaging Study
Key Details
Gender
All
Age Range
30 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2025-05-07
Completion Date
2025-11-30
Last Updated
2025-06-11
Healthy Volunteers
No
Conditions
Interventions
Brain imaging
fMRI session with the ALCUE paradigme.
Locations (1)
Psychiatric Center Copenhagen, Frederiksberg Hospital
Frederiksberg, Denmark