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RECRUITING
NCT06867809
NA

Spine and Brain Stimulation for Movement Recovery After Cervical Spinal Cord Injury

Sponsor: Jason Carmel

View on ClinicalTrials.gov

Summary

Stimulation of the spinal cord and brain represents a new experimental therapy that may have potential to restore movement after spinal cord injury. While some scientists have begun to study the effect of electrical stimulation on patient's ability to walk and move their legs after lower spinal cord injury, the use of stimulation of the upper (cervical) spine to restore arm and hand function after cervical spinal cord injury remains less well explored. The investigators are doing this research study to improve understanding of whether cervical spinal cord stimulation and brain stimulation can be used to improve arm and hand function. To do this, the investigators will combine spine stimulation (in the form of electrical stimulation from electrical stimulation wires temporarily implanted next to the cervical spinal cord) and brain stimulation (in the form of transcranial magnetic stimulation). The investigators will perform a series of experiments over 29 days to study whether these forms of stimulation can be applied and combined to provide improvement in arm and hand function.

Official title: Pilot Study to Evaluate the Safety and Tolerability of Spinal Cord Stimulation (SCS) and Paired Spine And Brain Stimulation For Movement Recovery After Spinal Cord Injury (SCI)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

20

Start Date

2026-01-15

Completion Date

2027-03-31

Last Updated

2025-10-30

Healthy Volunteers

No

Interventions

DEVICE

Epidural spinal cord stimulation and paired spine and brain stimulation

The spinal cord and brain stimulator allows for stimulation of the spinal cord and brain. Spinal cord stimulation (SCS) is provided by temporarily implanted SCS catheter electrode leads (Medtronic) that are connected to an external stimulator (Digitimer); brain stimulation is provided by transcranial magnetic stimulation (TMS).

Locations (2)

NewYork-Presbyterian Hospital / Columbia University Irving Medical Center (NYPH/CUIMC)

New York, New York, United States

NewYork-Presbyterian Allen Hospital / Columbia University Irving Medical Center (NYPH/CUIMC)

New York, New York, United States