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Rheological Functions of Erythrocyte in ESRD
Sponsor: Chang Gung Memorial Hospital
Summary
End-stage renal disease (ESRD) disrupts erythrocyte deformability due to osmotic imbalances, oxidative stress, and uremic toxins, leading to impaired microcirculation and oxygen transport. Dysregulation of ion channels, particularly the Gardos channel, exacerbates dehydration and eryptosis, further compromising vascular integrity. Given the critical role of erythrocyte flexibility in oxygen delivery, this study investigates its relationship with aerobic capacity in ESRD patients, highlighting potential mechanisms of microvascular dysfunction
Official title: The Effect of Osmotic Stress in Erythrocyte Rheology in ESRD Patients
Key Details
Gender
All
Age Range
20 Years - Any
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2022-08-24
Completion Date
2025-03-26
Last Updated
2025-03-11
Healthy Volunteers
Yes
Conditions
Interventions
Blood collection
Erythrocyte osmotic deformability was evaluated via osmotic gradient ektacytometry.
Cardiopulmonary exercise testing (CPET)
Cardiopulmonary Exercise Testing (CPET) is a non-invasive assessment that evaluates the integrated function of the cardiovascular, pulmonary, and muscular systems during exercise.
Locations (1)
Chang Gung University
Taoyuan District, Taiwan