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Adipose Tissue Gene Expression and Metabolomics Links to the Gut Microbiome-brain Axis
Sponsor: Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Summary
This study aims to understand how adipose tissue (fat) and the gut microbiota (the bacteria in the gut) may influence brain function and cognition. It has been observed that changes in adipose tissue in animals such as mice and Drosophila (a type of insect) affect memory and other brain functions. Additionally, it is believed that the gut microbiota also plays an important role in cognition. This study will explore how gene expression in adipose tissue, blood metabolites, and the gut microbiota are related to cognitive function, such as memory and thinking, in individuals with and without obesity. The investigation will also assess whether these factors can predict changes in the brain over time and how they influence sleep, physical activity, and blood sugar regulation. Advanced technologies will be used to analyze samples of tissue, blood, and microbiota, with the goal of identifying new mechanisms through which obesity affects the brain. This research may contribute to the development of new diagnostic and therapeutic strategies for cognitive problems in individuals with obesity.
Official title: Adipose Tissue Gene Expression and Metabolomics Links to the Gut Microbiome-brain Axis (POINSETTIA Study)
Key Details
Gender
All
Age Range
20 Years - Any
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2025-08-05
Completion Date
2027-01-31
Last Updated
2026-03-31
Healthy Volunteers
No
Conditions
Locations (1)
Institut d'Investigació Biomèdica de Girona (IDIBGI)
Girona, Girona, Spain