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Impact of Sarcopenia on Dyspnea in Patients With Asthma
Sponsor: University Hospital, Clermont-Ferrand
Summary
Dyspnea in asthma, is mainly due to airway obstruction but can be caused by several alternative diagnoses. The impact of sarcopenia on dyspnea in patients with asthma is unknown. Sarcopenic asthma had a reduced physical activity and is associated with airway obstruction compared to non-sarcopenic asthma. In patients with obstructive pulmonary disease, sarcopenia is associated with shallow breathing and diverse sensory and affective components of exertional dyspnea . The morbidity of sarcopenia is also increased by systemic inflammation and the production of inflammatory cytokines as found in inflammatory airway obstruction. The investigators will investigate the prevalence and impact of sarcopenia in asthmatics patients. This will enable to better manage sarcopenia in asthmatic patients, understand its origins and personalize treatment.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2025-03-25
Completion Date
2026-10
Last Updated
2025-03-11
Healthy Volunteers
No
Interventions
muscle evaluation
The investigators will evaluate the muscle mass and muscle strenght for all patients included
Dosage
Evaluation of the cinetic of biomarkers during exercise
Cardiopulmonary exercise test
CPET
Questionnaire and Physical Exam
Evaluating dyspnea, anxiety, sleep, physical activity, quality of life
Locations (1)
CHU Clermont-Ferrand
Clermont-Ferrand, France