Clinical Research Directory

Inclusion Criteria Participants must meet all of the following criteria: 1. Age 18 to 80 years. 2. 60±15 to 365±15 days after atrial fibrillation/atrial flutter (AF/AFL) ablation. 3. CHA2DS2-VA score ≥2. 4. No history of stroke, transient ischemic attack (TIA), or systemic embolism. 5. Continuous use of a NOAC since AF/AFL ablation. 6. No documented atrial tachyarrhythmia recurrence since ablation. 7. No antiarrhythmic drug (AAD) use within the past 2 months. 8. Able and willing to provide written informed consent. 9. Able and willing to comply with study procedures and follow-up. Exclusion Criteria Participants will be excluded if any of the following criteria are present: 1. High risk of post-ablation recurrence (e.g. including premature atrial contraction burden \>3% on any ambulatory ECG/Holter recording). 2. Moderate-to-severe mitral stenosis (mitral valve area ≤2.0 cm²) or mechanical heart valve. 3. Increased bleeding risk, including any of the following: 1. Current ISTH major bleeding or clinically relevant non-major bleeding (CRNMB). 2. History of non-traumatic major bleeding (e.g., intracranial, intraocular, spinal, retroperitoneal, gastrointestinal, or intra-articular) unless the reversible cause has been permanently eliminated. 3. Unresolved intracranial aneurysm/vascular malformation, or active/unhealed gastric or duodenal ulcer. 4. General anesthesia surgery within the past 3 months. 5. Planned surgery within the next 3 months. 6. Known bleeding diathesis (e.g., hemophilia). 7. Uncontrolled hypertension (SBP \>180 mmHg and/or DBP \>110 mmHg). 8. Hemoglobin \<90 g/L or blood transfusion within 4 weeks prior to enrollment. 9. Platelet count \<50 × 10⁹/L. 10. End-stage kidney disease (eGFR \<15 mL/min/1.73 m²) or on dialysis. 11. Severe liver disease (e.g., esophageal variceal bleeding, ascites, hepatic encephalopathy, or jaundice). 12. Known intolerance to oral anticoagulants or contraindication to oral anticoagulation. 4. Any condition requiring continued oral anticoagulation (e.g., pulmonary embolism, deep vein thrombosis, hypertrophic cardiomyopathy, cardiac amyloidosis). 5. Conditions associated with high non-cardioembolic stroke risk, including carotid, vertebral, or intracranial arterial stenosis ≥70%. 6. Prior left atrial appendage (LAA) occlusion, surgical LAA excision/closure, or intraoperative confirmation of LAA electrical isolation. 7. Female participants who are pregnant or breastfeeding, or of childbearing potential not using effective contraception. 8. Life expectancy \<2 years. 9. Current participation in another interventional clinical trial. 10. Any condition that, in the investigator's judgment, would make the participant unsuitable for the study.