Clinical Research Directory

Inclusion Criteria: 1\. The age of the subjects is 40-80 years old; 2. The subject meets one of the following metabolic disease components: ① abdominal B - ultrasound shows fatty liver or fat infiltration; ② arterial blood pressure is higher than 130/85mmHg, or the subject is on antihypertensive treatment; ③ prediabetes or type 2 diabetes, with fasting blood glucose above 6.1mmol/L; ④ overweight or obesity, with BMI of 24.0kg/m² or more, or male waist circumference of 90cm or more, female waist circumference of 85cm or more, or excessive body fat content and percentage. \- Exclusion Criteria: 1. People who are allergic to any of the pharmaceutical ingredients used in this study; A history of alcohol abuse (drinking more than 14 units of alcohol per week :1 unit = 285mL for beer, 25mL for spirits, 100mL for wine); 2. Patients who received probiotics within 1 month before taking the experimental drug; 3. Recent history of gastrointestinal bleeding, obstruction, perforation, tumor and other serious organic diseases; 4. Aminotransferase index \> 3 times the normal value; 5. Kidney disease (creatinine index higher than normal); 6. Patients with serious psychological and mental diseases, resulting in the inability to express themselves normally; 7. Patients with infectious liver diseases, such as hepatitis B and C; 8. The female subject is breastfeeding or has a positive pregnancy test result during the screening period or during the test -