Clinical Research Directory

Inclusion Criteria: 1. Be at least 25 years of age; 2. Have no contraindications to MRI 3. Have received 8 or more years of formal education 4. Be fluent in English 5. Cohort a. must be followed at Sunnybrook Health Sciences Center Cohort a: * Have been diagnosed with a suspected neurodegenerative disorder or traumatic brain injury (TBI) with memory deficits impacting functional status * In case of TBI, cognitive impairment has persisted at least three months post-injury * Received score of 16 or lower on the Mini Mental State Examination (MMSE) Cohort b: * Have no prior diagnosis of a neurodegenerative disorder or post-traumatic brain injury cognitive deficits * Be experiencing healthy aging and be age and sex matched to Cohort a. Exclusion Criteria: 1. Have any contraindications to MRI 2. Be pregnancy 3. Have any major comorbid medical conditions (as determined by investigators - e.g., comorbid neurological diseases, uncontrolled hypertension or diabetes, malignancy) or major comorbid psychiatric conditions (as determined by investigators - e.g., schizophrenia or bipolar disorder)