Clinical Research Directory

* Inclusion Criteria: * Adults aged 50 to 65 years (male and female) * Montreal Cognitive Assessment (MoCA) score ≥ 24 * No participation in any structured exercise intervention in the last 6 months * No exposure to altitudes above 1,500 m in the preceding 3 months * No chronic kidney, cardiovascular, metabolic, neurological, or orthopedic -disease * No history of significant respiratory conditions (e.g., asthma, exercise-induced -bronchospasm, dyspnea on exertion) * No current immunosuppressive treatment (e.g., corticosteroids, antidepressants) * No history of cancer or arthritis treatments * No recent blood donation (within the last 2 months) * Must be covered by a Social Security system or equivalent * Signed informed consent after receiving clear and transparent study information * Eligibility confirmed by a medical doctor during the inclusion process * Exclusion Criteria: * Active smoking * Major cardiovascular complications within the last 3 months (e.g., myocardial i-infarction, unstable angina, severe arrhythmias) * Severe hypertension (≥180 mmHg systolic or ≥110 mmHg diastolic) * Chronic respiratory insufficiency (e.g., COPD, sleep apnea) * Diabetes mellitus * Need for continuous or intermittent oxygen therapy * Participation in another clinical study at the same time * Use of corticosteroids or other systemic immunosuppressants * Any condition compromising safety or study compliance, as determined by the medical team * Pregnancy or breastfeeding * Legal or administrative protections (e.g., individuals under guardianship, persons deprived of liberty) * High baseline physical activity levels (PASE score \>90 indicating moderate-to-intense physical activity)