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Predictive Cardio-Metabolic Trascrictomics Trajectories In The Barilla Offspring Follow-Up Study
Sponsor: Azienda Ospedaliero-Universitaria di Parma
Summary
Experimental, drug-free, longitudinal, single-centre study for the prediction of cardiometabolic risk in Barilla Off-Spring Study subjects by analysing the evolution of transcriptomic signatures
Official title: Predictive Cardio-Metabolic Trascrictomics Trajectories In The Barilla Offspring Follow-Up STUDY: The PREDICT-OMICS Study.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
110
Start Date
2024-05-23
Completion Date
2025-12-31
Last Updated
2025-03-14
Healthy Volunteers
Yes
Conditions
Interventions
Evaluation of transcriptomic and cardio-metabolic profiles
The parameters and variables collected in 2006-2007 (T0) will be re-evaluated at the follow-up visit (T1), including demographic, anthropometric, lifestyle data (smoking habit, physical activity, sleep quality) blood pressure, standard biochemical analysis and inflammatory profile. To assess the evolution of glucose tolerance and vascular damage, metabolic (OGTT) and cardiovascular (carotid ecodoppler) profile analyses will be repeated. For gene expression analyses, in addition to messenger RNA from PBMCs (as at T0), RNA from PBMC-derived monocytes will also be extracted and sequenced at T1.
Locations (1)
University of Parma, Department of Medicine and Surgery
Parma, PR, Italy