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MR-Evaluation of Renal Function in Anesthetized Pediatric Patients
Sponsor: Uppsala University
Summary
The goal of this study is to investigate the effect of the anesthetic agents sevoflurane or propofol on the blood flow and oxygen delivery to the kidneys. Pediatric patients who are planned to undergo an MRI scan with generalized anesthesia will be randomized to either IV anesthesia with propofol or inhalation anesthesia with sevoflurane. Both of these anesthetic methods are commonly used for anesthesia on an everyday basis. In addition to the clinically indicated MRI, Multiparametric MRI will be performed to visualize the effect of the anesthetic agent on renal blood flow, perfusion and oxygenation.
Key Details
Gender
All
Age Range
1 Month - 14 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2025-10-01
Completion Date
2027-06-20
Last Updated
2025-03-25
Healthy Volunteers
No
Interventions
Anesthesia Maintenance Agent
Difference in renal blood flow (RBF) between Propofol and Sevoflurane groups. Quantified by specific Multiparametric MRI metrics (e.g., (Renal blood flow by phase contrast imaging) (regional perfusion by Arterial Spin labeling (ASL) and global and regional oxygenation by Blood oxygen dependent signal (BOLD))