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The Effect of Glucagon on Cerebral Glucose Metabolism in Healthy Humans
Sponsor: Nicolai Jacob Wewer Albrechtsen
Summary
This is a pilot study in which the investigators will investigate the effect of exogenous glucagon on cerebral glucose metabolism in healthy humans. Participants will participate in either part C or part D of the study, and each participant will participate in three study days. During a study day the participant will receive an intravenous infusion of either glucagon, glucose (in an adjustable rate to match to glucose concentrations achieved with the glucagon infusion) or saline. During each study day an 18F-flouro-deoxy-glucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) scan will be performed to quantify cerebral glucose metabolism during the first part (acute effect) of the glucagon/glucose/saline infusion (part C) or the last part (later effect) of the glucagon/glucose/saline infusion (part D).
Key Details
Gender
All
Age Range
55 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
12
Start Date
2025-03
Completion Date
2026-03
Last Updated
2025-03-24
Healthy Volunteers
Yes
Conditions
Interventions
Glucagon (part C)
90 minutes intravenous infusion with glucagon (infusion rate of 10 ng/kg/min).
Glucose clamp (part C)
90 minutes intravenous infusion of 20 % weight/volume glucose (in an ajustable rate to match the glucose levels achieved during the glucagon infusion).
Saline (part C)
90 minutes intravenous infusion with isotonic NaCl.
Glucagon (part D)
210 minutes intravenous infusion with glucagon (infusion rate of 10 ng/kg/min).
Glucose clamp (part D)
210 minutes intravenous infusion of 20 % weight/volume glucose (in an ajustable rate to match the glucose levels achieved during the glucagon infusion).
Saline (part D)
210 minutes intravenous infusion with isotonic NaCl.
Locations (1)
Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark
Copenhagen, Denmark