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NOT YET RECRUITING
NCT06877208
NA

The Effect of Glucagon on Cerebral Glucose Metabolism in Healthy Humans

Sponsor: Nicolai Jacob Wewer Albrechtsen

View on ClinicalTrials.gov

Summary

This is a pilot study in which the investigators will investigate the effect of exogenous glucagon on cerebral glucose metabolism in healthy humans. Participants will participate in either part C or part D of the study, and each participant will participate in three study days. During a study day the participant will receive an intravenous infusion of either glucagon, glucose (in an adjustable rate to match to glucose concentrations achieved with the glucagon infusion) or saline. During each study day an 18F-flouro-deoxy-glucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) scan will be performed to quantify cerebral glucose metabolism during the first part (acute effect) of the glucagon/glucose/saline infusion (part C) or the last part (later effect) of the glucagon/glucose/saline infusion (part D).

Key Details

Gender

All

Age Range

55 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

12

Start Date

2025-03

Completion Date

2026-03

Last Updated

2025-03-24

Healthy Volunteers

Yes

Interventions

OTHER

Glucagon (part C)

90 minutes intravenous infusion with glucagon (infusion rate of 10 ng/kg/min).

OTHER

Glucose clamp (part C)

90 minutes intravenous infusion of 20 % weight/volume glucose (in an ajustable rate to match the glucose levels achieved during the glucagon infusion).

OTHER

Saline (part C)

90 minutes intravenous infusion with isotonic NaCl.

OTHER

Glucagon (part D)

210 minutes intravenous infusion with glucagon (infusion rate of 10 ng/kg/min).

OTHER

Glucose clamp (part D)

210 minutes intravenous infusion of 20 % weight/volume glucose (in an ajustable rate to match the glucose levels achieved during the glucagon infusion).

OTHER

Saline (part D)

210 minutes intravenous infusion with isotonic NaCl.

Locations (1)

Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark

Copenhagen, Denmark