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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)
Sponsor: AstraZeneca
Summary
A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Tezepelumab in Adults with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD)
Official title: A Randomised, Double-blind, Placebo-controlled, Parallel Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Key Details
Gender
All
Age Range
40 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
990
Start Date
2025-03-25
Completion Date
2029-06-05
Last Updated
2026-03-04
Healthy Volunteers
No
Interventions
Tezepelumab
Tezepelumab subcutaneous injection
Placebo
Placebo subcutaneous injection
Locations (266)
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Cullman, Alabama, United States
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Phoenix, Arizona, United States
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Scottsdale, Arizona, United States
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Inglewood, California, United States
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Los Angeles, California, United States
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Palo Alto, California, United States
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Redding, California, United States
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San Diego, California, United States
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New Britain, Connecticut, United States
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Wilmington, Delaware, United States
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Bay Pines, Florida, United States
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Boynton Beach, Florida, United States
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Clearwater, Florida, United States
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Fleming Island, Florida, United States
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Jacksonville, Florida, United States
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Leesburg, Florida, United States
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Margate, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Miami Lakes, Florida, United States
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Ocala, Florida, United States
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Palmetto Bay, Florida, United States
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Winter Park, Florida, United States
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Adairsville, Georgia, United States
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Atlanta, Georgia, United States
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Cordele, Georgia, United States
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Decatur, Georgia, United States
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Fort Eisenhower, Georgia, United States
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Savannah, Georgia, United States
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Evanston, Illinois, United States
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Evansville, Indiana, United States
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Indianapolis, Indiana, United States
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Indianapolis, Indiana, United States
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Kansas City, Kansas, United States
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Bowling Green, Kentucky, United States
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Owensboro, Kentucky, United States
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Baltimore, Maryland, United States
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Potomac, Maryland, United States
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Ann Arbor, Michigan, United States
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Minneapolis, Minnesota, United States
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Hannibal, Missouri, United States
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Staten Island, New York, United States
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Syracuse, New York, United States
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Charlotte, North Carolina, United States
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Fayetteville, North Carolina, United States
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Oklahoma City, Oklahoma, United States
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Tulsa, Oklahoma, United States
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Grants Pass, Oregon, United States
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Sayre, Pennsylvania, United States
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Anderson, South Carolina, United States
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Columbia, South Carolina, United States
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Gaffney, South Carolina, United States
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Spartanburg, South Carolina, United States
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Union, South Carolina, United States
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Rapid City, South Dakota, United States
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Knoxville, Tennessee, United States
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Boerne, Texas, United States
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El Paso, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Lewisville, Texas, United States
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McKinney, Texas, United States
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Mesquite, Texas, United States
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San Antonio, Texas, United States
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Colchester, Vermont, United States
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Williamsburg, Virginia, United States
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Everett, Washington, United States
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Alberdi, Argentina
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Buenos Aires, Argentina
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Ciudad de Buenos Aires, Argentina
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Florida, Argentina
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La Plata, Argentina
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La Plata, Argentina
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Mar del Plata, Argentina
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Mendoza, Argentina
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Quilmes, Argentina
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Rosario, Argentina
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San Fernando, Argentina
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San Juan Bautista, Argentina
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Coffs Harbour, Australia
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Frankston, Australia
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Garran, Australia
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Nedlands, Australia
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New Lambton, Australia
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Spearwood, Australia
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Wollongong, Australia
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Woodville South, Australia
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Genk, Belgium
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Ghent, Belgium
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Jette, Belgium
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Leuven, Belgium
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Mechelen, Belgium
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Namur, Belgium
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Dupnitsa, Bulgaria
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Haskovo, Bulgaria
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Lovech, Bulgaria
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Pleven, Bulgaria
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Plovdiv, Bulgaria
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Rousse, Bulgaria
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Rousse, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Stara Zagora, Bulgaria
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Varna, Bulgaria
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Veliko Tanovo, Bulgaria
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Veliko Tarnovo, Bulgaria
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Vidin, Bulgaria
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Yambol, Bulgaria
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Armenia, Colombia
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Barranquilla, Colombia
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Bogotá, Colombia
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Cali, Colombia
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Ibagué, Colombia
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Manizales, Colombia
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Medellín, Colombia
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Medellín, Colombia
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Aalborg, Denmark
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Hvidovre, Denmark
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Næstved, Denmark
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Odense C, Denmark
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Vejle, Denmark
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Brest, France
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Lyon, France
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Marseille, France
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Montpellier, France
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Paris, France
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Paris, France
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Pessac, France
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Saint-Herblain, France
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Athens, Greece
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Athens, Greece
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Athens, Greece
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Heraklion, Greece
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Ioannina, Greece
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Pátrai, Greece
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Thessaloniki, Greece
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Thessaloniki, Greece
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Hong Kong, Hong Kong
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Hong Kong, Hong Kong
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Budapest, Hungary
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Debrecen, Hungary
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Edelény, Hungary
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Gödöllő, Hungary
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Hatvan, Hungary
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Mosonmagyaróvár, Hungary
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Nyíregyháza-Sóstóhegy, Hungary
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Törökbálint, Hungary
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Ashkelon, Israel
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Haifa, Israel
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Jerusalem, Israel
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Jerusalem, Israel
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Kfar Saba, Israel
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Ramat Gan, Israel
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Rehovot, Israel
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Tel Aviv, Israel
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Akashi-shi, Japan
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Chikushino-shi, Japan
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Chiyoda-ku, Japan
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Fukui-shi, Japan
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Fukuoka, Japan
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Fukuoka, Japan
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Gifu, Japan
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Iruma-Gun, Japan
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Ishinomaki, Japan
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Kasuga-shi, Japan
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Kitakyushu-shi, Japan
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Kiyose-shi, Japan
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Kiyose-shi, Japan
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Kobe, Japan
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Komatsu-shi, Japan
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Kure-shi, Japan
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Kyoto, Japan
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Matsusaka-shi, Japan
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Meguro-ku, Japan
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Minatoku, Japan
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Minatoku, Japan
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Miyazaki, Japan
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Mizunami-shi, Japan
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Nagaoka-shi, Japan
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Nagasaki, Japan
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Nagoya, Japan
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Nagoya, Japan
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Nagoya, Japan
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Nerima-ku, Japan
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Ohta-ku, Japan
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Okayama, Japan
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Okayama, Japan
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Osaka, Japan
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Sapporo, Japan
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Sendai, Japan
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Sendai, Japan
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Shinjuku-ku, Japan
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Shinjuku-ku, Japan
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Shinjuku-ku, Japan
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Shiogama, Japan
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Takamatsu, Japan
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Takatsuiki-shi, Japan
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Tanabe-shi, Japan
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Toshima-ku, Japan
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Ube, Japan
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Yokohama, Japan
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Yokohama, Japan
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Eindhoven, Netherlands
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Maastricht, Netherlands
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Rotterdam, Netherlands
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Rotterdam, Netherlands
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Zutphen, Netherlands
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Auckland, New Zealand
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Auckland, New Zealand
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Auckland, New Zealand
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Hamilton West, New Zealand
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Tauranga, New Zealand
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Cusco, Peru
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Lima, Peru
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Lima, Peru
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Lima, Peru
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Lima, Peru
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Lima, Peru
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Lima, Peru
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Lima, Peru
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Piura, Peru
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Bucharest, Romania
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Bucharest, Romania
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Cluj-Napoca, Romania
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Cluj-Napoca, Romania
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Oradea, Romania
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Timișoara, Romania
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Timișoara, Romania
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Benoni, South Africa
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Cape Town, South Africa
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Durban, South Africa
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Durban, South Africa
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eMkhomazi, South Africa
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Kimberley, South Africa
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Somerset West, South Africa
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Tygervalley, South Africa
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Gothenburg, Sweden
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Karlskrona, Sweden
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Lund, Sweden
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Örebro, Sweden
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Stockholm, Sweden
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Stockholm, Sweden
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Bang Kra So, Thailand
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Bangkok, Thailand
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Hat Yai, Thailand
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Muang, Thailand
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Muang, Thailand
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Mueang, Thailand
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Rayong, Thailand
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Adana, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Kayseri, Turkey (Türkiye)
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Kocaeli, Turkey (Türkiye)
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Mersin, Turkey (Türkiye)
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Da Nang, Vietnam
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Haiphong, Vietnam
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Hanoi, Vietnam
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Ho Chi Minh City, Vietnam
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Ho Chi Minh City, Vietnam
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Ho Chi Minh City, Vietnam
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Hồ Chí Minh, Vietnam
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Huế, Vietnam