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Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use
Sponsor: Massachusetts General Hospital
Summary
The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outcomes will include changes in depressive symptoms and cannabis use, as well as usability ratings.
Official title: AMP-C: A Digital Therapeutic for Reward Dysfunction in Co-Occurring Depression and Cannabis Use
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-02
Completion Date
2029-01
Last Updated
2026-02-27
Healthy Volunteers
No
Interventions
Amplification of Positivity - Cannabis Use (AMP-C)
AMP-C is a smartphone-based digital intervention that includes activities that focus on positivity (e.g., noticing and capitalizing on positive events) to increase positive emotions, thoughts, and behaviors. The role and impact of CU on the maintenance of depression and reward dysfunction (and vice versa), is intertwined throughout the intervention.
Locations (1)
Massachusetts General Hospital
Boston, Massachusetts, United States