Clinical Research Directory

Inclusion Criteria: 1. Age over 18 years old, gender not limited. 2. The patient voluntarily joined this study and signed informed consent 3. ECOG score is 0 or 1 4. Expected survival period ≥ 2 years. 5. Pathology and imaging diagnosis of non metastatic muscle invasive bladder cancer 6. There are assessable lesions that meet the RECIST 1.1 criteria 7. Enough organ function Exclusion Criteria: 1. Received systemic anti-tumor therapy 4 weeks before starting the study treatment 2. The toxicity and/or complications of previous anti-tumor treatments have not recovered to NCI-CTCAE ≤ 1 level 3. Subjects known or suspected to have interstitial pneumonia 4. Individuals with any active, known or suspected autoimmune diseases 5. There are clinical symptoms or diseases of the heart that have not been well controlled 6. Diagnosed with any other malignant tumor 7. Subjects who have experienced severe infections within 28 days prior to their first medication use 8. History of immunodeficiency 9. Use of attenuated live vaccine within 28 days prior to the first study medication 10. Have undergone major surgery within 28 days prior to the first administration of medication