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Cross-validation of a Predictive Model of Response to Anti-TNF Alpha Based on Oxylipin Response in Rheumatoid Arthritis
Sponsor: University Hospital, Clermont-Ferrand
Summary
The goal of this clinical trial is to use a blood test to predict whether a participant diagnosed with rheumatoid arthritis will respond to anti-TNF alpha treatment . The main questions it aims to answer is: Is the predictive model created using oxylipins effective? Participants starting anti-TNF alpha treatment will have a blood sample taken before starting treatment and 6 months afterwards.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-03-15
Completion Date
2027-11-01
Last Updated
2025-03-17
Healthy Volunteers
No
Conditions
Interventions
Blood sample Truculture
blood sample added to the standard blood test at visit Inclusion and Month 6. This project will use the TruCulture® Whole Blood Stimulation System to assess the Whole Blood Oxylipin Response (WBOR). WBOR is the ability of patients to produce oxylipins in response to an immune stimulus. One tube is conditioned with LPS stimulant and a control tube is conditioned with no stimulant (Null).
Locations (3)
CHU Clermont-Ferrand
Clermont-Ferrand, France
Hopital Cochin, APHP
Paris, France
CHU Saint Etienne
Saint-Etienne, France