Clinical Research Directory

Inclusion Criteria: * Patients aged 18-75. * History of Type 2 Diabetes Mellitus at least 5 years prior to enrollment. * HbA1c level ≥6.5% * Use of at least 1 oral antidiabetic agent and no changes in the last 30 days. * History of essential hypertension with systolic Blood pressure of 160 mmHg or more (≥150 mmHg in patient with Type 2 Diabetes Mellitus), despite compliance with three of more antihypertensive drugs. * Stable drug regimen of at least 3 antihypertensive medications with no changes for 2 weeks before enrollment. Exclusion Criteria: * Estimated glomerular filtration rate of less than 30 mL/min per 1.73m2. * Type 1 diabetes mellitus. * History of aortic pathologies such as aneurysm or dissection confirmed by immediate preprocedural angiography that would preclude the Endovascular Denervation (EDN) procedure. * Orthostatic hypotension. * Acute or severe systemic infection. * History of myocardial infarction, unstable angina, or cerebrovascular accident in the previous 3 months. * History of previous renal artery CDN. * Pregnancy or planned pregnancy during the study period. * Unable to provide informed consent.