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NCT06880887
PHASE1

Nervus Vagus Stimulation and Cerebral Palsy

Sponsor: Istanbul Medipol University Hospital

View on ClinicalTrials.gov

Summary

When the literature is reviewed, it is difficult to find direct research on the effects of auricular vagus nerve stimulation (aVNS) on the autonomic nervous system and spasticity in children with spastic cerebral palsy. However, there is a substantial body of literature on the potential of vagus nerve stimulation (VNS) to modulate autonomic functions. The aim of this study is to investigate the potential effects of vagus nerve stimulation, which is known to influence the autonomic nervous system, in individuals with spastic cerebral palsy and to explore its contributions to spasticity.

Official title: The Acute Effects of Vagus Nerve Stimulation on the Autonomic Nervous System and Spasticity in Children with Spastic Cerebral Palsy

Key Details

Gender

All

Age Range

2 Years - 15 Years

Study Type

INTERVENTIONAL

Enrollment

14

Start Date

2025-03-01

Completion Date

2025-05-01

Last Updated

2025-03-18

Healthy Volunteers

No

Interventions

OTHER

nervus vagus stimulation

Vagus stimulation was applied bilaterally through the ear in a transcutaneous manner. transcutaneous auricular VNS (taVNS) was performed using the Vagustim device. The stimulation was applied for 20 minutes with a pulse width of 300 microseconds, a frequency of 10 Hz, and in a biphasic manner. The electrodes were placed on the concha and tragus parts of the ear, and the current was increased until the participant could feel it.

Locations (1)

Mudanya University

Bursa, Bursa, Turkey (Türkiye)