Clinical Research Directory

Inclusion Criteria: 1. The current episode met the DSM-5 diagnostic criteria for major depression, without psychotic symptoms of the first or recurrent drug-free depressive subjects 2. After a full course of treatment with two or more antidepressants, the patient had no response, and the level of treatment resistance was moderate to severe as assessed by the Maudsley staging method 3.24-item Hamilton depression Scale score ≥20 4.The age ranged from 18 to 45 years, both sexes 5.Right handed 6.Written informed consent was obtained and patients volunteered to participate in the study and be evaluated. Exclusion Criteria: * 1\. Comorbidity with other mental disorders, including schizophrenia, mental retardation, substance dependence, etc. 2\. Suffering from serious or unstable physical diseases 3, pregnant, lactating women, women of childbearing age screening period urine HCG test results are positive 4\. Subjects with metal objects in the body or other contraindications to MRI scanning 5\. There are other conditions considered by the investigator to be inappropriate for participation in the clinical trial.