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Human Umbilical Cord Mesenchymal Stem Cells Treatment in Sepsis
Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Summary
The primary objective: To evaluate the efficacy of intravenous infusion of universal UC-MSCs and CD83+MSCs subpopulation injection in the treatment of sepsis by using the 28-day survival rate of the subjects as the primary efficacy criterion.The secondary objectives: 1. To systematically evaluate the safety of universal UC-MSCs and CD83+MSCs subpopulation in the treatment of sepsis; 2. To provide theoretical basis and clinical research data for establishing a safe, effective and feasible clinical treatment plan for sepsis using stem cells.
Official title: Clinical Study on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Sepsis
Key Details
Gender
All
Age Range
0 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
180
Start Date
2025-05-22
Completion Date
2027-12-31
Last Updated
2025-05-25
Healthy Volunteers
No
Conditions
Interventions
CD83-positive MSC
90 patients are infused with 1×10⁸ stem cells per session and receive regulatory treatment
regulatory MSC
45 patients are infused with 1×10⁸ stem cells per session and receive regulatory treatment
control solution
45 patients are infused with equal volume of control solution and receive regulatory treatment
Locations (1)
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Chongqing, Chongqing Municipality, China