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RECRUITING
NCT06882811
EARLY_PHASE1

Human Umbilical Cord Mesenchymal Stem Cells Treatment in Sepsis

Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

View on ClinicalTrials.gov

Summary

The primary objective: To evaluate the efficacy of intravenous infusion of universal UC-MSCs and CD83+MSCs subpopulation injection in the treatment of sepsis by using the 28-day survival rate of the subjects as the primary efficacy criterion.The secondary objectives: 1. To systematically evaluate the safety of universal UC-MSCs and CD83+MSCs subpopulation in the treatment of sepsis; 2. To provide theoretical basis and clinical research data for establishing a safe, effective and feasible clinical treatment plan for sepsis using stem cells.

Official title: Clinical Study on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Sepsis

Key Details

Gender

All

Age Range

0 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

180

Start Date

2025-05-22

Completion Date

2027-12-31

Last Updated

2025-05-25

Healthy Volunteers

No

Conditions

Interventions

BIOLOGICAL

CD83-positive MSC

90 patients are infused with 1×10⁸ stem cells per session and receive regulatory treatment

BIOLOGICAL

regulatory MSC

45 patients are infused with 1×10⁸ stem cells per session and receive regulatory treatment

OTHER

control solution

45 patients are infused with equal volume of control solution and receive regulatory treatment

Locations (1)

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Chongqing, Chongqing Municipality, China