Clinical Research Directory

Inclusion Criteria: * Patients with COPD receiving home non-invasive ventilation for chronic respiratory failure under the Lane Fox Respiratory Service at Guy's and St Thomas' NHS Foundation Trust * Tolerating home non-invasive ventilation for at least 4 hours/24 hours * Aged 18-80 years old * Able to communicate symptom burden to the research team * Able to give informed consent for participation in the study * Clinical stability, with no acute exacerbations of COPD for 2 weeks prior to enrolment Exclusion Criteria: * Severe, non-respiratory organ dysfunction including, but not limited to: * Congestive cardiac failure * Significant cardiovascular disease * End-stage malignancy * End-stage renal failure * Acute pulmonary pathology requiring emergency treatment including, but not limited to: * Pneumonia * Pneumothorax * Pulmonary embolism * Severe cognitive impairment * Psychosocial factors that would preclude completion of the study protocol