Clinical Research Directory

Inclusion Criteria: * Persons who have received full information about the organization of the research and have given their oral consent to participate. * Male or female 18 years of age or older; * Carrier of venous thrombotic SAPL: * Not favoured by a major or ≥ 2 minor favouring factors, if the patient doesn't present with obstetrical SAPL in accordance with the ACR/EULAR 2023 clinical classification criteria. * Or favored by ≥ 2 minors, if the patient has obstetrical SAPL: severe preeclampsia \< 34 weeks or placental insufficiency * Regardless of how long the disease has been present * With persistent positivity of at least one biological criterion: * Positivity of circulating lupus anticoagulant or IgG anticardiolipid or IgG anti-beta-2GPI * And persistence of the same positive test ≥ 12 weeks apart * And With maximum delay of positivity of the 1st antiphospholipid test of 3 years after the thrombotic event * Current anticoagulant treatment, regardless of date of introduction * rivaroxaban or apixaban * or antivitamin K * Patient affiliated to a social security system Exclusion Criteria: * Venous thrombotic event motivating current anticoagulant treatment favoured by a major favouring factor: * Active cancer * Hospitalization with bed rest for at least 3 days in the 3 months preceding the event * Major trauma with fractures or spinal cord injury in the month preceding the event * Surgery with general/spinal/epidural anesthesia for \> 30 minutes in the 3 months preceding the event. * In the absence of a history of pre-eclampsia or placental insufficiency: venous thrombotic event motivating current anticoagulant treatment favoured by 2 or more minor favouring factors: * Systemic autoimmune disease or active inflammatory bowel disease * Acute/severe infection * Central venous catheter in the same vascular bed * Hormone replacement therapy, estrogenic oral contraceptives, or hormone-stimulating therapy in progress * Long-distance travel (≥ 8 hours) * Obesity (BMI ≥ 30 kg/m²) * Pregnancy or post-partum (6 weeks after delivery) * Prolonged immobilization * Surgery with general/spinal/epidural anesthesia for \< 30 minutes in the 3 months preceding the event * Known triple antiphospholipid positivity * Isolated IgM antiphospholipid positivity * History of known arterial thrombosis * History of known microcirculatory thrombosis * Known SAPL-related cardiac valvular disease * Persons referred to in articles L. 1121-5, L. 1121-7 and L1121-8 of the Public Health Code * Persons deprived of their liberty by judicial or administrative decision, persons under psychiatric care under articles L. 3212-1 and L. 3213-1. * Glomerular filtration rate \< 30ml/min. * Weight \< 50kg * History of thrombotic recurrence under well-administered anticoagulant therapy.