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Effect of Mannitol on Propofol Level
Sponsor: Cukurova University
Summary
Group 1 will include 20 patients aged 18 years and over, American Society of Anesthesiologist (ASA) II-III class, who will undergo supratentorial tumor surgery, and Group 2 will include 20 patients who will undergo pituitary surgery without mannitol. Total intravenous anesthesia (TIVA) will be adjusted to propofol 4 µg/dl and remifentanil 2-4 µg/dl with target-controlled infusion pumps. In the mannitol group, 2.5 ml/kg (0.5 g/kg) will be given to all patients 20 minutes after induction and the mannitol infusion will be adjusted to be 10 minutes.In Group 2, mannitol will not be used and 2.5 ml/kg isotonic will be administered in 10 minutes. Both blood and urine samples will take for measurement to propofol levels.
Official title: Propofol Level at TCI During Mannitol
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-03-20
Completion Date
2025-10-30
Last Updated
2025-09-02
Healthy Volunteers
No
Conditions
Interventions
mannitol
2.5 mg/kg Mannitol will be given intravenously
Saline
2.5 ml/kg saline will be given as plasebo
Locations (1)
Çukurova University
Çukurova, Adana, Turkey (Türkiye)