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Telomeres Length in Israeli Fibrotic ILD Patients
Sponsor: Barzilai Medical Center
Summary
Individuals with fibrotic interstitial lung diseases (FILD) will be recruited after providing informed consent. in addition to routine data as usually collected in the clinic, blood samples will be taken for measurement of telomeres length in peripheral blood leukocytes using both the Telomere Restriction Fragment (TRF) Analysis method and Nanopore sequencing. Participants with FILD will be followed-up for 2-year after recruitment, including clinical and pulmonary function tests at-least every 6 months, or more frequently, according to the treating physician discretion.
Official title: Short Telomeres in Familial and Sporadic Fibrotic Interstitial Lung Diseases in Israel
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2026-02
Completion Date
2028-12
Last Updated
2026-02-25
Healthy Volunteers
Yes
Conditions
Interventions
leukocyte telomere length (LTL) will be measured using the Telomere Restriction Fragment (TRF) Analysis method
Peripheral blood leukocytes telomere length will be measured both by TRF analysis and by Nanopore sequencing. Both analyses will be conducted at the laboratory of Prof. Yehuda Tzfati at the Hebrew University, which is highly experienced in the field of telomere biology and in telomere length analysis. Blood samples will be taken once from each participant. No genetic sequencing will be performed as part of this study.
Locations (2)
Barzilai Medical Center
Ashkelon, Israel
Tel Aviv Medical Center
Tel Aviv, Israel