Clinical Research Directory

Inclusion Criteria: 1. Voluntary, written, signed informed consent to participate in this study; 2. be able to complete the study in accordance with the requirements of the test protocol; 3. Age 4-14 years old; 4. Meet the diagnostic criteria for allergic rhinitis established in the Guidelines for the Diagnosis and Treatment of Allergic Rhinitis in Children (2022 Revised Edition); 5. Symptoms: 2 or more symptoms: sneezing, watery discharge, nasal itching and nasal congestion and other symptoms last or accumulate for more than 1 hour per day, and may be accompanied by eye symptoms such as itching, watery eyes and red eyes; 6. Signs: pale and edema of the nasal mucosa, which may be accompanied by watery discharge; Exclusion Criteria: 1. Drugs that affect the intestinal flora (including antimicrobial drugs, microecological preparations, intestinal mucosal protectors, Chinese patent medicines, etc.) have been used continuously for more than 1 week within 1 month before screening; 2. Patients with pulmonary tuberculosis; 3. Combined with allergic asthma; 4. Those with nasal polyps or severe nasal septum deviation; 5. Patients with severe systemic diseases or malignant tumors; 6. Those with congenital genetic diseases and congenital immunodeficiency diseases; 7. Those who regularly use probiotics or prebiotics within 6 months before the screening period; 8. Those with severe digestive tract diseases (including severe diarrhea, inflammatory bowel disease, etc.); 9. Patients with metabolic syndrome (including obesity, dyslipidemia, hypertension, diabetes, etc.); 10. Patients with sinusitis, otitis media, or respiratory tract infection; 11. Those who are allergic to the probiotic-related ingredients used in this trial; 12. Those who stop taking the test sample or add other drugs in the middle of the test, and the efficacy cannot be judged or the data is incomplete; 13. Those who take items with similar functions to the test in a short period of time, which affects the judgment of the results; 14. Subjects who are unable to participate in the test due to their own reasons; 15. Subjects who are judged by other investigators to be insuitable to participate.