Clinical Research Directory

Inclusion Criteria: * Sickle Cell Disease Diagnosis * Chronic non-vaso-occlusive pain experienced on average ≥ 3 days per week for \> 6 months (based on a response of "Most days," "Every day," or "Some days" and not "Never" to the question "In the past 6 months, how often have you had pain?") * Ability to speak, read, write, and understand English * A Mediterranean Eating Pattern for Americans (MEPA-III) score \<13, indicating that they do not follow a Mediterranean diet. Exclusion Criteria: * Having taken systemic antimicrobials (to treat an infection in the previous 4 weeks) * History of colon cancer or inflammatory bowel disease (given potential untoward effects on the gut microbiome) * History of Clostridium difficile infection in the preceding 12 weeks; (4) unable to agree to maintain physical activity at the current level for the duration of the study * Currently following a Mediterranean diet, vegan diet, or dietary restrictions (e.g., religious, food intolerance/allergy) that preclude adoption of a Mediterranean diet * Lack of access to a space to safely store and reheat food items * Living in a facility that provides meals. * Pregnancy or breastfeeding * More than 7 in-patient hospital stays in the last year * Currently receiving dialysis treatment