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Phenotypic and Transcriptomic Description of Megakaryocytes in Sickle Cell Patient
Sponsor: University Hospital, Toulouse
Summary
Sickle cell disease is the most common inherited blood disorder in the world. Chronic hemolysis induces platelet activation and chronic inflammation. Platelets and megakaryocyte, as medullar platelets precursors, are known to play a role in innate immunity. Little is known about the role of megakaryocytes at basal state and during acute complication in sickle cell disease patients. The aim of this study is to evaluate the role of megakaryocytes in sickle cell disease.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2025-03-13
Completion Date
2028-04-01
Last Updated
2025-03-20
Healthy Volunteers
No
Conditions
Locations (1)
CHU de Toulouse
Toulouse, France, France