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Comparing Hydrocortisone and Prednisolone for Community Acquired Pneumonia (CAP)
Sponsor: Copenhagen Respiratory Research
Summary
The goal of this cluster randomized controlled trial is to determine the optimal treatment for community aquired pneumonia (CAP). The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 18 years old diagnosed with severe CAP. The main question is whether there is a difference in all cause mortality within thirty days. Participants will be randomized to receive treatment with either hydrocortisone or prednisolone.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1600
Start Date
2026-03-10
Completion Date
2030-11-01
Last Updated
2026-03-18
Healthy Volunteers
No
Conditions
Interventions
Methylprednisolone (drug)
ATC code: H02AB06. Can be changed to Prednisolone 50 mg orally.
hydrocortisone
ATC-code: H02AB09. Can be changed to 50 mg x 4 daily orally if appropriate.
Locations (14)
Bornholm Hospital
Rønne, Bornholm, Denmark
Amager Hospital
Copenhagen, Copenhagen City, Denmark
Bispebjerg Hospital
Copenhagen, Copenhagen City, Denmark
Frederiksberg Hospital
Frederiksberg, Copenhagen City, Denmark
Gentofte Hospital
Hellerup, Copenhagen City, Denmark
Herlev Hospital
Herlev, Copnhagen Surroundings, Denmark
Hvidovre Hospital
Hvidovre, Copnhagen Surroundings, Denmark
Nordsjællands Hospital
Hillerød, North Zealand, Denmark
Holbæk Sygehus
Holbæk, Region Sjælland, Denmark
University Hospital of Region Zealand, Køge
Køge, Region Sjælland, Denmark
Næstved Sygehus
Næstved, Region Sjælland, Denmark
Ringsted Sygehus
Ringsted, Region Sjælland, Denmark
University Hospital of Region Zealand, Roskilde
Roskilde, Region Sjælland, Denmark
Slagelse Sygehus
Slagelse, Region Sjælland, Denmark