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PHArmacotherapy Assessed Using Neuroprobing With TransOsseal Magnetic Stimulation
Sponsor: Insel Gruppe AG, University Hospital Bern
Summary
The goal of this observational study is to investigate how prescribed anti-seizure medications (ASMs) affect cortical excitability in adults with epilepsy. The main questions it aims to answer are: 1. Does the magnitude of transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) measured with electroencephalography (EEG) change between OFF and ON medication states? 2. Do these changes in TEP amplitude persist over time? Researchers will compare each participant's measurements in the OFF state with those in the ON state to see if TEPs change following ASM (re)start. Participants will undergo one TMS-EEG session scheduled around their prescribed ASM (re)start and one 1-6 months later.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2024-10-21
Completion Date
2029-10
Last Updated
2025-03-24
Healthy Volunteers
No
Conditions
Interventions
TMS-EEG
Evoked brain activity is measured with the help of TMS-EEG in epilepsy patients OFF and ON medication.
Locations (1)
University Hospital Bern
Bern, Switzerland