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Orthobiologic Treatment for Knee Osteoarthritis
Sponsor: University Hospital of North Norway
Summary
The goal of this randomized clinical trial is to compare treatment for osteoarthritis in the knee using platelet rich plasma (PRP) or adipose stem cells (ADS). The main questions it aims to answer are: * Will the patients clinically benefit from the treatment, and if so, which treatment is better? * Will there be radiological findings to support this? Participants will be randomized into one of four groups: PRP, ADS, PRP + ADS or placebo treatment (saline) and will be examined and get an X-ray and MRI of the knee taken at inclusion and after 1 and 2 years.
Official title: Orthobiologic Treatment for Knee Osteoarthritis (Ortobiologisk Behandling av Kneleddsartrose)
Key Details
Gender
All
Age Range
40 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2024-09-23
Completion Date
2027-12
Last Updated
2025-03-25
Healthy Volunteers
No
Conditions
Interventions
PRP injection
Platelet rich plasma, blood from the patient that is centrifuged.
ADSTEM Inj. (Adult human mesenchymal stem cells)
Adipose tissue stem cells, from abdominal fat.
Injection
PRP + adipose tissue stem cells
Saline (NaCl 0,9 %) (placebo)
Sterile saline injection.
Locations (1)
University Hospital in Northern Norway
Tromsø, Tromsø, Norway