Clinical Research Directory
Browse clinical research sites, groups, and studies.
Mechanism of Ketogenic Diet-Induced Hypercholesterolemia
Sponsor: Washington University School of Medicine
Summary
Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify "responders" who develop high cholesterol on a ketogenic diet, and will measure rates of production and removal of certain types of cholesterol-carrying particles called lipoproteins in responders. The results will clarify the mechanism by which a ketogenic diet can cause high cholesterol in certain susceptible people.
Key Details
Gender
All
Age Range
18 Years - 39 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2025-02-24
Completion Date
2030-11-30
Last Updated
2026-03-23
Healthy Volunteers
Yes
Conditions
Interventions
Ketogenic Diet
Participants will consume an isocaloric ketogenic diet for 4 weeks with all food provided as packed-out meals.
Control Diet
Participants will consume an isocaloric control diet for 4 weeks with all food provided as packed-out meals.
Locations (1)
Washington University School of Medicine
St Louis, Missouri, United States