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Oral Tranexamic Acid After Total Knee Arthroplasty
Sponsor: Rush University Medical Center
Summary
This is a prospective, double-blind, randomized controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in total knee arthroplasty (TKA). The study will assess pain, function, and range of motion (ROM) over a 2-year period, with key evaluations at 6 weeks and 90 days postoperatively. Hypothesis: Patients receiving 1.95g oral TXA for 3 or 7 days post-op will show improved pain, function, and ROM at 6 weeks and 90 days, with similar blood loss and transfusion rates as the control group.
Official title: Prolonged Oral Tranexamic Acid Use in Primary Total Joint Arthroplasty: A Double Blind Randomized Placebo Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
351
Start Date
2026-06-01
Completion Date
2027-05-01
Last Updated
2026-02-23
Healthy Volunteers
No
Conditions
Interventions
tranexamic acid Oral-Short Arm
1.95g Tranexamic acid daily for post op days 1 to 3
tranexamic acid Oral-Long Arm
1.95g tranexamic acid daily post op days 1-7
Control group placebo
Placebo for 3 days post-op